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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-25882

Burckhardt, C J; Greber, U F (2009). Virus movements on the plasma membrane support infection and transmission between cells. PLoS Pathogens, 5(11):e1000621.

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Abstract

How viruses are transmitted across the mucosal epithelia of the respiratory, digestive, or excretory tracts, and how they spread from cell to cell and cause systemic infections, is incompletely understood. Recent advances from single virus tracking experiments have revealed conserved patterns of virus movements on the plasma membrane, including diffusive motions, drifting motions depending on retrograde flow of actin filaments or actin tail formation by polymerization, and confinement to submicrometer areas. Here, we discuss how viruses take advantage of cellular mechanisms that normally drive the movements of proteins and lipids on the cell surface. A concept emerges where short periods of fast diffusive motions allow viruses to rapidly move over several micrometers. Coupling to actin flow supports directional transport of virus particles during entry and cell-cell transmission, and local confinement coincides with either nonproductive stalling or infectious endocytic uptake. These conserved features of virus-host interactions upstream of infectious entry offer new perspectives for anti-viral interference.

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44 citations in Web of Science®
44 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:November 2009
Deposited On:15 Jan 2010 11:11
Last Modified:12 Nov 2014 12:25
Publisher:Public Library of Science (PLoS)
ISSN:1553-7366
Publisher DOI:10.1371/journal.ppat.1000621
PubMed ID:19956678

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