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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-25882

Burckhardt, C J; Greber, U F (2009). Virus movements on the plasma membrane support infection and transmission between cells. PLoS Pathogens, 5(11):e1000621.

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Abstract

How viruses are transmitted across the mucosal epithelia of the respiratory, digestive, or excretory tracts, and how they spread from cell to cell and cause systemic infections, is incompletely understood. Recent advances from single virus tracking experiments have revealed conserved patterns of virus movements on the plasma membrane, including diffusive motions, drifting motions depending on retrograde flow of actin filaments or actin tail formation by polymerization, and confinement to submicrometer areas. Here, we discuss how viruses take advantage of cellular mechanisms that normally drive the movements of proteins and lipids on the cell surface. A concept emerges where short periods of fast diffusive motions allow viruses to rapidly move over several micrometers. Coupling to actin flow supports directional transport of virus particles during entry and cell-cell transmission, and local confinement coincides with either nonproductive stalling or infectious endocytic uptake. These conserved features of virus-host interactions upstream of infectious entry offer new perspectives for anti-viral interference.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:November 2009
Deposited On:15 Jan 2010 11:11
Last Modified:27 Nov 2013 19:48
Publisher:Public Library of Science
ISSN:1553-7366
Publisher DOI:10.1371/journal.ppat.1000621
PubMed ID:19956678
Citations:Web of Science®. Times Cited: 43
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Scopus®. Citation Count: 43

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