Quick Search:

is currently disabled due to reindexing of the ZORA database. Please use Advanced Search.
uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2599

Studer, G; Furrer, K; Davis, B J; Stoeckli, S S; Zwahlen, R A; Luetolf, U M; Glanzmann, C (2006). Postoperative IMRT in head and neck cancer. Radiation Oncology, 1 : 40:1-8.

[img]
Preview
PDF
1MB

Abstract

BACKGROUND: Aim of this work was to assess loco-regional disease control in head and neck cancer (HNC) patients treated with postoperative intensity modulated radiation therapy (pIMRT). For comparative purposes, risk features of our series have been analysed with respect to histopathologic adverse factors. Results were compared with an own historic conventional radiation (3DCRT) series, and with 3DCRT and pIMRT data from other centres. Between January 2002 and August 2006, 71 patients were consecutively treated with pIMRT for a squamous cell carcinoma (SCC) of the oropharynx (32), oral cavity (22), hypopharynx (7), larynx (6), paranasal sinus (3), and an unknown primary, respectively. Mean and median follow up was 19 months (2-48), and 17.6 months. 83% were treated with IMRT-chemotherapy. Mean prescribed dose was 66.3 Gy (60-70), delivered with doses per fraction of 2-2.3 Gy, respectively. RESULTS: 2-year local, nodal, and distant control rates were 95%, 91%, and 96%, disease free and overall survival 90% and 83%, respectively. The corresponding survival rates for the subgroup of patients with a follow up time >12 months (n = 43) were 98%, 95%, 98%, 93%, and 88%, respectively. Distribution according to histopathologic risk features revealed 15% and 85% patients with intermediate and high risk, respectively. All loco-regional events occurred in the high risk subgroup. CONCLUSION: Surgery followed by postoperative IMRT in patients with substantial risk for recurrence resulted in high loco-regional tumor control rates compared with large prospective 3DCRT trials.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Cranio-Maxillofacial Surgery
DDC:610 Medicine & health
Language:English
Date:2006
Deposited On:16 Jun 2008 15:53
Last Modified:28 Nov 2013 00:25
Publisher:BioMed Central
ISSN:1748-717X
Additional Information:Free full text article
Publisher DOI:10.1186/1748-717X-1-40
Official URL:http://www.ro-journal.com/content/pdf/1748-717X-1-40.pdf
PubMed ID:17052346
Citations:Web of Science®. Times Cited: 18
Google Scholar™
Scopus®. Citation Count: 15

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page