Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26042

Läubli, H; Borsig, L (2009). Heparins attenuate cancer metastasis: are selectins the link? Cancer Investigation, 27(5):474-481.

Accepted Version
View at publisher


Heparin is often used to prevent or treat thromboembolism in cancer patients. Clinical and experimental evidence suggest that heparin also has anti-cancer activities. Experimental evidence consistently supports the ability of heparin to attenuate metastasis. The potential anti-metastatic effects of heparin include the inhibition of cell-cell interactions or heparanase and modulation of growth factors and anticoagulant activity. Heparin inhibits selectin-mediated interactions of tumor cells with leukocytes, platelets and endothelial cells, which are likely to mediate the initial steps of hematogenous metastasis. Prospective clinical trials can be designed based on the insights obtained from experimental studies.


12 citations in Web of Science®
14 citations in Scopus®
Google Scholar™



58 downloads since deposited on 19 Jan 2010
17 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Date:June 2009
Deposited On:19 Jan 2010 15:24
Last Modified:05 Apr 2016 13:39
Publisher:Informa Healthcare
Additional Information:This is an electronic version of an article published in Cancer Investigation. 2009 Jun;27(5):474-81. Cancer Investigation is available online at http://informahealthcare.com/doi/abs/10.1080/07357900802647136
Publisher DOI:10.1080/07357900802647136
PubMed ID:19479484

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page