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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-261

Biehlmaier, O; Alam, M; Schmidt, W J (2007). A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry International, 50(1):189-195.

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Abstract

The retinal dopamine (DA) deficiency is an important feature of the pathogenesis in Parkinson's disease (PD) visual dysfunction. Systemic inhibition of complex I (rotenone) in rats has been proposed as a model of PD. In this study, we investigated whether systemic inhibition of complex I can induce impairment of DA-ergic cells in the retina, similar to the destruction of retinal cells found in PD patients. Rotenone (2.5mg/kg i.p., daily) was administered over 60 days. Neurochemically, rotenone treated rats showed a depletion of DA in the striatum and substantia nigra (SN). In addition, the number of retinal DA-ergic amacrine cells was significantly reduced in the rotenone treated animals. This study is the first one giving highlight towards a deeper understanding of systemic complex I inhibition (rotenone as an environmental toxin) and the connection between both, DA-ergic degeneration in the nigrostriatal pathway, and in the DA-ergic amacrine cells of the retina.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
DDC:570 Life sciences; biology
590 Animals (Zoology)
Uncontrolled Keywords:parkinsons disease, retina, rat, dopamin, amacrine cells
Language:English
Date:01 January 2007
Deposited On:11 Feb 2008 13:14
Last Modified:27 Nov 2013 17:53
Publisher:Elsevier
ISSN:0197-0186
Publisher DOI:10.1016/j.neuint.2006.08.001
PubMed ID:16962686
Citations:Web of Science®. Times Cited: 14
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