Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-261
Biehlmaier, O; Alam, M; Schmidt, W J (2007). A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochemistry International, 50(1):189-195.
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The retinal dopamine (DA) deficiency is an important feature of the pathogenesis in Parkinson's disease (PD) visual dysfunction. Systemic inhibition of complex I (rotenone) in rats has been proposed as a model of PD. In this study, we investigated whether systemic inhibition of complex I can induce impairment of DA-ergic cells in the retina, similar to the destruction of retinal cells found in PD patients. Rotenone (2.5mg/kg i.p., daily) was administered over 60 days. Neurochemically, rotenone treated rats showed a depletion of DA in the striatum and substantia nigra (SN). In addition, the number of retinal DA-ergic amacrine cells was significantly reduced in the rotenone treated animals. This study is the first one giving highlight towards a deeper understanding of systemic complex I inhibition (rotenone as an environmental toxin) and the connection between both, DA-ergic degeneration in the nigrostriatal pathway, and in the DA-ergic amacrine cells of the retina.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Zoology (former)|
|DDC:||570 Life sciences; biology
590 Animals (Zoology)
|Uncontrolled Keywords:||parkinsons disease, retina, rat, dopamin, amacrine cells|
|Date:||1 January 2007|
|Deposited On:||11 Feb 2008 12:14|
|Last Modified:||27 Nov 2013 16:53|
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