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Molecular pathways of aging and hypertension


Camici, G G; Sudano, I; Noll, G; Tanner, F C; Lüscher, T F (2009). Molecular pathways of aging and hypertension. Current Opinion in Nephrology and Hypertension, 18(2):134-137.

Abstract

PURPOSE OF REVIEW: This review is aimed at describing the latest advances made in understanding the pathogenesis of vascular aging and hypertension and their underlying molecular mechanisms. RECENT FINDINGS: p66shc and endothelin-1 are highly implicated in vascular aging and hypertension, respectively. Increased production of reactive oxygen species observed in aging and hypertension may provide the missing link interconnecting endothelin-1 and p66shc. Through several studies performed in animal models and patients, both of these targets have been shown to be highly implicated, although differently, in the pathogenesis of aging and hypertension. SUMMARY: Future research should be directed toward elucidating a mediator or set of mediators which regulate these targets and which may be the common denominator underlying molecular aspects of vascular aging and hypertension.

PURPOSE OF REVIEW: This review is aimed at describing the latest advances made in understanding the pathogenesis of vascular aging and hypertension and their underlying molecular mechanisms. RECENT FINDINGS: p66shc and endothelin-1 are highly implicated in vascular aging and hypertension, respectively. Increased production of reactive oxygen species observed in aging and hypertension may provide the missing link interconnecting endothelin-1 and p66shc. Through several studies performed in animal models and patients, both of these targets have been shown to be highly implicated, although differently, in the pathogenesis of aging and hypertension. SUMMARY: Future research should be directed toward elucidating a mediator or set of mediators which regulate these targets and which may be the common denominator underlying molecular aspects of vascular aging and hypertension.

Citations

16 citations in Web of Science®
21 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2009
Deposited On:21 Dec 2009 12:22
Last Modified:05 Apr 2016 13:40
Publisher:Lippincott Wiliams & Wilkins
ISSN:1062-4821
Publisher DOI:10.1097/MNH.0b013e328326093f
PubMed ID:19434051

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