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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26254

Reck, M; Stahel, R A; von Pawel, J; Karthaus, M; Korfee, S; Serke, M; Schuette, W H W; Eschbach, C; Fink, T H; Leschinger, M I; Manegold, C (2010). Pemetrexed in the treatment of malignant mesothelioma: Results from an expanded access program in Germany. Respiratory Medicine, 104(1):142-148.

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An international expanded access program was initiated to provide access to treatment with pemetrexed prior registration and reimbursement for malignant mesothelioma (MM). Chemonaïve and pretreated patients with inoperable MM of the pleura or peritoneum were eligible. This report describes the results obtained in German centers. Investigators could choose between three treatments: Pemetrexed 500mg/m(2) alone (P) or in combination with cisplatin 75mg/m(2) (PC) or carboplatin AUC 5 (PCb). From November 2002 to June 2004, a total of 567 patients (554 with pleural MM; 41% pretreated) were included. Of 548 evaluable patients with pleural MM, 191 received P, 137 PC and 220 PCb. Patients in the P group were more often pretreated (70%) and had worse performance status compared with the other groups. In the P, PC, and PCb groups overall response rate (ORR) was 16%, 24% and 18%, median time to progression (TTP) was 5.5, 8.2, and 6.9 months, and median overall survival (OS) was 8.7, 11.3 and 9.7 months respectively. Efficacy outcomes were better for chemonaïve than for pretreated patients, and P was less hematotoxic than PC or PCb. Treatment of pleural MM with pemetrexed alone or in combination with platinum was safe and active as first and second-line therapy.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
DDC:610 Medicine & health
Date:January 2010
Deposited On:12 Jan 2010 13:28
Last Modified:27 Nov 2013 18:47
Publisher DOI:10.1016/j.rmed.2009.07.019
PubMed ID:19818589
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 8

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