Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Kumar, K; Tang, C S; Rossetti, F F; Textor, M; Keller, B; Vörös, J; Reimhult, E (2009). Formation of supported lipid bilayers on indium tin oxide for dynamically-patterned membrane-functionalized microelectrode arrays. Lab on a Chip, 9(5):718-725.

Full text not available from this repository.

Abstract

Supported lipid bilayers (SLBs) are ideal platforms for the study of membrane proteins and function. Assembly of functional SLBs in an array format would lead to a breakthrough in high-throughput screening of membrane-associated processes, e.g., drugs binding to transmembrane proteins. We report the formation of SLBs from the rupture of anionic vesicles in the presence of Ca(2+) ions on ITO-coated surfaces and characterise the assembly and SLB properties. Furthermore, the formation, manipulation and regeneration of SLBs adsorbed on ITO microelectrode array spots using an electric potential switch are demonstrated. This platform enables addressable assembly and the study of electrochemically mediated membrane processes in a microarray format which can be regenerated in situ.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:2009
Deposited On:22 Dec 2009 13:48
Last Modified:27 Nov 2013 20:43
Publisher:Royal Society of Chemistry
ISSN:1473-0189
Publisher DOI:10.1039/b814281e
PubMed ID:19224023
Citations:Web of Science®. Times Cited: 17
Google Scholar™
Scopus®. Citation Count: 18

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page