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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26362

Ghosh, A; Haiss, F; Sydekum, E; Schneider, R; Gullo, M; Wyss, M T; Mueggler, T; Baltes, C; Rudin, M; Weber, B; Schwab, M E (2010). Rewiring of hindlimb corticospinal neurons after spinal cord injury. Nature Neuroscience, 13(1):97-104.

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Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex. Voltage-sensitive dye (VSD) imaging and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) revealed a stable expansion of the forelimb sensory map, covering in particular the former hindlimb cortex containing the rewired neurons. Therefore, axotomised hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > Institute of Biomedical Engineering
04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
170 Ethics
610 Medicine & health
Deposited On:04 Jan 2010 11:26
Last Modified:05 Apr 2016 13:41
Publisher:Nature Publishing Group
Publisher DOI:10.1038/nn.2448
PubMed ID:20010824

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