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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26538

Schreiner, B; Heppner, F L; Becher, B (2009). Modeling multiple sclerosis in laboratory animals. Seminars in Immunopathology, 31(4):479-495.

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Abstract

Inflammatory demyelinating disease of the central nervous system is one of the most frequent causes of neurological disability in young adults. While in situ analysis and in vitro models do shed some light onto the processes of tissue damage and cellular interactions, the development of neuroinflammation and demyelination is a far too complex process to be adequately modeled by simple test tube systems. Thus, animal models using primarily genetically modified mice have been proven to be of paramount importance. In this chapter, we discuss recent advances in modeling brain diseases focusing on murine models and report on new tools to study the pathogenesis of complex diseases such as multiple sclerosis.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:November 2009
Deposited On:12 Jan 2010 16:18
Last Modified:27 Nov 2013 19:49
Publisher:Springer
ISSN:1863-2297
Publisher DOI:10.1007/s00281-009-0181-4
PubMed ID:19802608
Citations:Web of Science®. Times Cited: 18
Google Scholar™
Scopus®. Citation Count: 22

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