Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26558
Vogler, C; Spalek, K; Aerni, A; Demougin, P; Müller, A; Huynh, K D; Papassotiropoulos, A; de Quervain, D J F (2009). CPEB3 is associated with human episodic memory. Frontiers in Behavioral Neuroscience, 3(Articl):5pp.
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Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans, the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism that influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data suggest a role for human CPEB3 in human episodic memory.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||06 Jan 2010 13:50|
|Last Modified:||28 Oct 2014 16:00|
|Publisher:||Frontiers Research Foundation|
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