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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26771

Moormann, A M; Heller, K N; Chelimo, K; Embury, P; Ploutz-Snyder, R; Otieno, J A; Oduor, M; Münz, C; Rochford, R (2009). Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses. International Journal of Cancer, 124(7):1721-1726.

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Abstract

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in equatorial Africa and is linked to Epstein-Barr virus (EBV) and Plasmodium falciparum coinfections early in life. Epstein-Barr nuclear antigen 1 (EBNA1) is the sole viral latent antigen expressed in BL tumors. Loss of EBNA1-specific immune surveillance could allow eBL emergence. Therefore, EBNA1-specific T cell responses were analyzed by IFN-gamma ELISPOT in Kenyan children with eBL and compared to healthy children with divergent malaria exposure. Significantly fewer children with eBL, 16% (7/44) had EBNA1-specific IFN-gamma responses in contrast to healthy children living in a malaria holoendemic area or in an area with sporadic malaria transmission, 67% (40/60) and 72% (43/60) responders, respectively (p < 0.003). Children with eBL maintained IgG(1) dominated antibody responses to EBNA1 similar to healthy children suggesting a selective loss of IFN-gamma secreting EBNA1-specific T cells in the presence of intact humoral immunity. CD8(+) T cell responses to EBV lytic and latent antigens not expressed in the tumors were similarly robust in eBL patients compared to healthy children. In addition, CD4(+) T cell responses to a malaria protein, merozoite surface protein 1, were present in lymphoma patients. This study demonstrates a selective loss of EBNA1-specific T cell responses in children with eBL and suggests a potential immunotherapeutic target for this EBV-associated lymphoma.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:11 Jan 2010 12:02
Last Modified:27 Nov 2013 21:39
Publisher:Wiley-Blackwell
ISSN:0020-7136
Additional Information:The definitive version is available at www.blackwell-synergy.com
Publisher DOI:10.1002/ijc.24014
PubMed ID:19089927
Citations:Web of Science®. Times Cited: 19
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Scopus®. Citation Count: 22

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