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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26772

Münz, C (2009). Enhancing immunity through autophagy. Annual Review of Immunology, 27:423-449.

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Abstract

Next to the proteasome, autophagy is the main catabolic pathway for the degradation of cytoplasmic constituents. The immune system uses it both as an effector mechanism to clear intracellular pathogens and as a mechanism to monitor its products for evidence of pathogen invasion and cellular transformation. Because autophagy delivers intracellular material for lysosomal degradation, its products are primarily loaded onto MHC class II molecules and are able to stimulate CD4+ T cells. This process might shape the self-tolerance of the CD4+ T cell repertoire and stimulate CD4+ T cell responses against pathogens and tumors. Beyond antigen processing, autophagy's role in cell survival is to assist the clonal expansion of B and T cells for efficient adaptive immune responses. These immune-enhancing functions make autophagy an attractive target for therapeutic manipulation in human disease.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:11 Jan 2010 13:06
Last Modified:27 Nov 2013 18:21
Publisher:Annual Reviews
ISSN:0732-0582
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1146/annurev.immunol.021908.132537
PubMed ID:19105657
Citations:Web of Science®. Times Cited: 1
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Scopus®. Citation Count: 118

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