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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26776

Münz, C; Lünemann, J D; Getts, M T; Miller, S D (2009). Antiviral immune responses: triggers of or triggered by autoimmunity? Nature Reviews. Immunology, 9(4):246-258.

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The predisposition of individuals to several common autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, is genetically linked to certain human MHC class II molecules and other immune modulators. However, genetic predisposition is only one risk factor for the development of these diseases, and low concordance rates in monozygotic twins, as well as the geographical distribution of disease risk, suggest the involvement of environmental factors in the development of these diseases. Among these environmental factors, infections have been implicated in the onset and/or promotion of autoimmunity. In this Review, we outline the mechanisms by which viral infection can trigger autoimmune disease and describe the pathways by which infection and immune control of infectious disease might be dysregulated during autoimmunity.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Jan 2010 14:06
Last Modified:28 Nov 2013 01:04
Publisher:Nature Publishing Group
Publisher DOI:10.1038/nri2527
PubMed ID:19319143
Citations:Web of Science®. Times Cited: 137
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Scopus®. Citation Count: 153

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