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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26777

Strowig, T; Gurer, C; Ploss, A; Liu, Y F; Arrey, F; Sashihara, J; Koo, G; Rice, C M; Young, J W; Chadburn, A; Cohen, J I; Münz, C (2009). Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. Journal of Experimental Medicine, 206(6):1423-1434.

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Abstract

Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted human immune system components control infection with the oncogenic and persistent Epstein-Barr virus (EBV). These cytotoxic and interferon-gamma-producing T cell responses were human leukocyte antigen (HLA) restricted and specific for EBV-derived peptides. In HLA-A2 transgenic animals and similar to human EBV carriers, T cell responses against lytic EBV antigens dominated over recognition of latent EBV antigens. T cell depletion resulted in elevated viral loads and emergence of EBV-associated lymphoproliferative disease. Both loss of CD4(+) and CD8(+) T cells abolished immune control. Therefore, this mouse model recapitulates features of symptomatic primary EBV infection and generates T cell-mediated immune control that resists oncogenic transformation.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:13 Jan 2010 11:08
Last Modified:27 Nov 2013 22:21
Publisher:Rockefeller University Press
ISSN:0022-1007
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1084/jem.20081720
PubMed ID:19487422
Citations:Web of Science®. Times Cited: 84
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