Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26778

Lünemann, A; Lünemann, J D; Münz, C (2009). Regulatory NK-cell functions in inflammation and autoimmunity. Molecular Medicine, 15(9-10):352-358.

View at publisher


Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiation of an adaptive immune response against infection and tumor development. However, it has become clear that NK cells interact with various components of the immune system, and therefore have the potential to function as regulatory cells. While NK cells can assist in dendritic cell (DC) maturation and T-cell polarization, increasing evidence indicates that NK cells can also prevent and limit adaptive (auto) immune responses via killing of autologous myeloid and lymphoid cells. Investigating immunoregulatory NK-cell functions might generate exciting insights into the reciprocal regulation between NK-cell-mediated innate immunity and adaptive immune responses, improve our capacity to monitor these cells as surrogate markers for disease activity and treatment responses in autoimmune diseases, and, perhaps, provide new prospects for NK cell-directed therapies.


48 citations in Web of Science®
55 citations in Scopus®
Google Scholar™



52 downloads since deposited on 10 Jan 2010
8 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:10 Jan 2010 13:09
Last Modified:05 Apr 2016 13:43
Publisher:North Shore Long Island Jewish Research Institute
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.2119/molmed.2009.00035
PubMed ID:19603102

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page