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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26781

Gannagé, M; Dormann, D; Albrecht, R; Dengjel, J; Torossi, T; Rämer, P C; Lee, M; Strowig, T; Arrey, F; Conenello, G; Pypaert, M; Andersen, J; García-Sastre, A; Münz, C (2009). Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host & Microbe, 6(4):367-380.

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Influenza A virus is an important human pathogen causing significant morbidity and mortality every year and threatening the human population with epidemics and pandemics. Therefore, it is important to understand the biology of this virus to develop strategies to control its pathogenicity. Here, we demonstrate that influenza A virus inhibits macroautophagy, a cellular process known to be manipulated by diverse pathogens. Influenza A virus infection causes accumulation of autophagosomes by blocking their fusion with lysosomes, and one viral protein, matrix protein 2, is necessary and sufficient for this inhibition of autophagosome degradation. Macroautophagy inhibition by matrix protein 2 compromises survival of influenza virus-infected cells but does not influence viral replication. We propose that influenza A virus, which also encodes proapoptotic proteins, is able to determine the death of its host cell by inducing apoptosis and also by blocking macroautophagy.


183 citations in Web of Science®
187 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Experimental Immunology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:10 Jan 2010 11:03
Last Modified:05 Apr 2016 13:43
Publisher DOI:10.1016/j.chom.2009.09.005
PubMed ID:19837376

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