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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-26781

Gannagé, M; Dormann, D; Albrecht, R; Dengjel, J; Torossi, T; Rämer, P C; Lee, M; Strowig, T; Arrey, F; Conenello, G; Pypaert, M; Andersen, J; García-Sastre, A; Münz, C (2009). Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host & Microbe, 6(4):367-380.

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Abstract

Influenza A virus is an important human pathogen causing significant morbidity and mortality every year and threatening the human population with epidemics and pandemics. Therefore, it is important to understand the biology of this virus to develop strategies to control its pathogenicity. Here, we demonstrate that influenza A virus inhibits macroautophagy, a cellular process known to be manipulated by diverse pathogens. Influenza A virus infection causes accumulation of autophagosomes by blocking their fusion with lysosomes, and one viral protein, matrix protein 2, is necessary and sufficient for this inhibition of autophagosome degradation. Macroautophagy inhibition by matrix protein 2 compromises survival of influenza virus-infected cells but does not influence viral replication. We propose that influenza A virus, which also encodes proapoptotic proteins, is able to determine the death of its host cell by inducing apoptosis and also by blocking macroautophagy.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:10 Jan 2010 11:03
Last Modified:27 Nov 2013 18:43
Publisher:Elsevier
ISSN:1931-3128
Publisher DOI:10.1016/j.chom.2009.09.005
PubMed ID:19837376
Citations:Web of Science®. Times Cited: 126
Google Scholar™
Scopus®. Citation Count: 129

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