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Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation


Handschin, C (2009). Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation. Clinical and Experimental Pharmacology and Physiology, 36(12):1139-1143.

Abstract

1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to
undernourishment has been the predominant problem, the inflammatory response to obesity and other life style-associated diseases gained in relevance in Western societies in the last hundred years.
2. Traditionally, fat tissue has been considered as the major source of proinflammatory secreted factors in these pathologies. In recent years however, the contribution of other tissues to a disease-causing chronic inflammation has been increasingly appreciated.
3. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is one of the key regulatory factors in the active skeletal muscle. Aberrant expression of PGC-1α in inactive muscle fibers could link a sedentary life style, persistent systemic inflammation and the higher risk for many chronic diseases. Modulation of PGC-1α activity in skeletal muscle might accordingly have a broad therapeutic effect. Here, recent advances in the understanding of the role of muscle PGC-1α in health and disease are reviewed.

1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to
undernourishment has been the predominant problem, the inflammatory response to obesity and other life style-associated diseases gained in relevance in Western societies in the last hundred years.
2. Traditionally, fat tissue has been considered as the major source of proinflammatory secreted factors in these pathologies. In recent years however, the contribution of other tissues to a disease-causing chronic inflammation has been increasingly appreciated.
3. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is one of the key regulatory factors in the active skeletal muscle. Aberrant expression of PGC-1α in inactive muscle fibers could link a sedentary life style, persistent systemic inflammation and the higher risk for many chronic diseases. Modulation of PGC-1α activity in skeletal muscle might accordingly have a broad therapeutic effect. Here, recent advances in the understanding of the role of muscle PGC-1α in health and disease are reviewed.

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19 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:08 University Research Priority Programs > Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2009
Deposited On:17 Jan 2010 09:09
Last Modified:05 Apr 2016 13:44
Publisher:Wiley-Blackwell
ISSN:0305-1870
Additional Information:The definitive version is available at www3.interscience.wiley.com
Publisher DOI:10.1111/j.1440-1681.2009.05275.x
PubMed ID:19671064
Permanent URL: http://doi.org/10.5167/uzh-27079

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