Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27385

Schäffer, L; Luzi, F; Burkhardt, T; Rauh, M; Beinder, E (2009). Antenatal betamethasone administration alters stress physiology in healthy neonates. Obstetrics and Gynecology, 113(5):1082-1088.

[img]Published Version
PDF - Registered users only
693Kb

Abstract

OBJECTIVE: To analyze hypothalamic-pituitary-adrenal axis balance in healthy newborns after antenatal betamethasone treatment for lung maturation where delivery could be prolonged until or near term. METHODS: In a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions and in response to a pain-induced stress event in 23 neonates with antenatal exposure to a single course of betamethasone (2x12 mg) and compared with 40 controls. The mean interval between betamethasone treatment and delivery was 60+/-23 days. RESULTS: On day 4 of life, neonates in the control group exhibited a significant increase in cortisol and cortisone from baseline levels after the stress induction (1.175-2.4 ng/mL for cortisol and 11.35-18.15 ng/mL for cortisone [both P<.05]), whereas, in betamethasone-exposed neonates, cortisol and cortisone stress response was not significantly different from baseline levels (1.39-1.6 ng/mL for cortisone [P=.76] and 14.8-17.1 ng/mL for cortisol [P=.69]). No influence of gestational age at betamethasone administration (P=.76) or gestational age at delivery (P=.71) on stress response patterns was observed in a multiple stepwise regression. CONCLUSION: A single course of antenatal betamethasone treatment induces a suppression of stress reactivity in healthy newborns.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:24 Feb 2010 11:28
Last Modified:10 Dec 2012 01:04
Publisher:Lippincott Wiliams & Wilkins
ISSN:0029-7828
Publisher DOI:10.1097/AOG.0b013e3181a1f0e6
PubMed ID:19384124
Citations:Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page