Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2739

Abraham, D; Distler, O (2007). How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Research and Therapy, 9 (Sup:1-10.

View at publisher


A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.


56 citations in Web of Science®
67 citations in Scopus®
Google Scholar™



35 downloads since deposited on 22 Aug 2008
17 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Aug 2008 12:03
Last Modified:05 Apr 2016 12:24
Publisher:BioMed Central
Additional Information:Free full text article
Publisher DOI:10.1186/ar2186
Official URL:http://arthritis-research.com/content/pdf/ar2186.pdf
PubMed ID:17767740

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page