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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2739

Abraham, D; Distler, O (2007). How does endothelial cell injury start? The role of endothelin in systemic sclerosis. Arthritis Research and Therapy, 9 (Sup:1-10.

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Abstract

A considerable amount of research time has been invested in studies aimed at elucidating pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for biomedical science remain, such as identification of the key factors that determine susceptibility to SSc, and elucidation of the precise nature of the initiating event that causes endothelial cell injury and ultimately brings about the biological cascade(s) that lead to the pathologic vascular changes. Involved factors are likely to include genetic perturbations, environmental cues, tissue injury, infection and hypoxia/oxidative stress. As important as determining the initiating events are the identification and characterization of key factors that are functionally important in driving vascular disease progression, because these factors are potential targets for therapeutic intervention. This article reviews the role of endothelin as an example of a pleiotropic mediator with effects on various aspects of SSc pathogenesis, such as inflammation, vasculopathy and tissue remodelling.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:610 Medicine & health
Language:English
Date:2007
Deposited On:22 Aug 2008 14:03
Last Modified:27 Nov 2013 18:37
Publisher:BioMed Central
ISSN:1478-6354
Additional Information:Free full text article
Publisher DOI:10.1186/ar2186
Official URL:http://arthritis-research.com/content/pdf/ar2186.pdf
PubMed ID:17767740
Citations:Web of Science®. Times Cited: 47
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