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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27418

Abraham, D J; Krieg, T; Distler, J; Distler, O (2009). Overview of pathogenesis of systemic sclerosis. Rheumatology, 48(Suppl ):iii3-iii7.

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Abstract

The aetiology of SSc is subject to ongoing research, as the precise events that underlie the development of this disease remain unclear. The pathogenesis is known to involve endothelium, epithelium, fibroblasts, innate and adaptive immune systems and their component immunological mediators. Endothelial cell damage may be the initiating factor, but the precise triggering event(s) remain elusive. Angiogenesis also appears to be dysregulated. Vasculopathy shows similarities in different organs (e.g. pulmonary arterial hypertension, renal disease, digital tip ulcers). Endothelin-1 is a potent mediator of vasculopathy, and hence represents a highly relevant target for intervention of vascular features in SSc.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:18 Jan 2010 09:53
Last Modified:27 Nov 2013 17:59
Publisher:Oxford University Press
ISSN:1462-0324
Publisher DOI:10.1093/rheumatology/ken481
PubMed ID:19487220
Citations:Web of Science®. Times Cited: 63
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Scopus®. Citation Count: 77

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