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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27478

Neumann, M (2009). Molecular neuropathology of TDP-43 proteinopathies. International Journal of Molecular Sciences, 10(1):232-246.

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Abstract

The identification of TDP-43 as the major component of the pathologic inclusions in most forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) resolved a long-standing enigma concerning the nature of the ubiquitinated disease protein under these conditions. Anti-TDP-43 immunohistochemistry and the recent development of novel tools, such as phosphorylation-specific TDP-43 antibodies, have increased our knowledge about the spectrum of pathological changes associated with FTLD-U and ALS and moreover, facilitated the neuropathological routine diagnosis of these conditions. This review summarizes the recent advances in our understanding on the molecular neuropathology and pathobiology of TDP-43 in FTLD and ALS.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:30 Jan 2010 17:49
Last Modified:27 Nov 2013 20:59
Publisher:Molecular Diversity Preservation International (MDPI)
ISSN:1422-0067
Publisher DOI:10.3390/ijms10010232
PubMed ID:19333444
Citations:Web of Science®. Times Cited: 50
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