Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27478
Neumann, M (2009). Molecular neuropathology of TDP-43 proteinopathies. International Journal of Molecular Sciences, 10(1):232-246.
View at publisher
The identification of TDP-43 as the major component of the pathologic inclusions in most forms of sporadic and familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS) resolved a long-standing enigma concerning the nature of the ubiquitinated disease protein under these conditions. Anti-TDP-43 immunohistochemistry and the recent development of novel tools, such as phosphorylation-specific TDP-43 antibodies, have increased our knowledge about the spectrum of pathological changes associated with FTLD-U and ALS and moreover, facilitated the neuropathological routine diagnosis of these conditions. This review summarizes the recent advances in our understanding on the molecular neuropathology and pathobiology of TDP-43 in FTLD and ALS.
78 downloads since deposited on 30 Jan 2010
24 downloads since 12 months
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||30 Jan 2010 16:49|
|Last Modified:||27 Nov 2013 19:59|
|Publisher:||Molecular Diversity Preservation International (MDPI)|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page