Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27523
Fellay, J; Ge, D; Shianna, K V; Colombo, S; Ledergerber, B; Cirulli, E T; Urban, T J; Zhang, K; Gumbs, C E; Smith, J P; Castagna, A; Cozzi-Lepri, A; De Luca, A; Easterbrook, P; Günthard, H F; Mallal, S; Mussini, C; Dalmau, J; Martinez-Picado, J; Miro, J M; Obel, N; Wolinsky, S M; Martinson, J J; Detels, R; Margolick, J B; Jacobson, L P; Descombes, P; Antonarakis, S E; Beckmann, J S; O'Brien, S J; Letvin, N L; McMichael, A J; Haynes, B F; Carrington, M; Feng, S; Telenti, A; Goldstein, D B (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genetics, 5(12):e1000791.
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
|Contributors:||NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)|
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases|
|DDC:||610 Medicine & health|
|Deposited On:||26 Jan 2010 12:27|
|Last Modified:||27 Nov 2013 22:34|
|Publisher:||Public Library of Science|
|Free access at:||PubMed ID. An embargo period may apply.|
|Citations:||Web of Science®. Times cited: 133|
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