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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27523

Fellay, J; Ge, D; Shianna, K V; Colombo, S; Ledergerber, B; Cirulli, E T; Urban, T J; Zhang, K; Gumbs, C E; Smith, J P; Castagna, A; Cozzi-Lepri, A; De Luca, A; Easterbrook, P; Günthard, H F; Mallal, S; Mussini, C; Dalmau, J; Martinez-Picado, J; Miro, J M; Obel, N; Wolinsky, S M; Martinson, J J; Detels, R; Margolick, J B; Jacobson, L P; Descombes, P; Antonarakis, S E; Beckmann, J S; O'Brien, S J; Letvin, N L; McMichael, A J; Haynes, B F; Carrington, M; Feng, S; Telenti, A; Goldstein, D B (2009). Common genetic variation and the control of HIV-1 in humans. PLoS Genetics, 5(12):e1000791.

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Abstract

To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.

Contributors:NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:26 Jan 2010 11:27
Last Modified:27 Nov 2013 21:34
Publisher:Public Library of Science
ISSN:1553-7390
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:10.1371/journal.pgen.1000791
PubMed ID:20041166
Citations:Web of Science®. Times Cited: 161
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Scopus®. Citation Count: 184

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