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Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor


Mueller, N J; Weisser, M; Fehr, T; Wüthrich, R P; Müllhaupt, B; Lehmann, R; Imhof, A; Aubert, J D; Genoni, M; Kunz, R; Weber, M; Steiger, J (2010). Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor. Transplant Infectious Disease, 12(1):54-59.

Abstract

N.J. Mueller, M. Weisser, T. Fehr, R.P. Wüthrich, B. Müllhaupt, R. Lehmann, A. Imhof, J.-D. Aubert, M. Genoni, R. Kunz, M. Weber, J. Steiger. Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor. Transpl Infect Dis 2009. All rights reserved Abstract: The growing need for organs and the scarcity of donors has resulted in an increased use of extended criteria donors. We report a case where a recipient of a cardiac graft was used as an organ donor. Death of the recipient occurred 9 days after transplantation and was attributed to presumed cerebral hemorrhage, which post mortem was diagnosed as invasive aspergillosis of the brain. One recipient of a kidney transplant lost the graft due to infection with Aspergillus fumigatus, whereas prompt initiation of therapy successfully prevented disseminated aspergillosis in the other recipients. Despite the pressure to extend the use of organs by lowering the acceptance criteria, organs should only be accepted if the cause of death of the donors is unequivocally explained.

N.J. Mueller, M. Weisser, T. Fehr, R.P. Wüthrich, B. Müllhaupt, R. Lehmann, A. Imhof, J.-D. Aubert, M. Genoni, R. Kunz, M. Weber, J. Steiger. Donor-derived aspergillosis from use of a solid organ recipient as a multiorgan donor. Transpl Infect Dis 2009. All rights reserved Abstract: The growing need for organs and the scarcity of donors has resulted in an increased use of extended criteria donors. We report a case where a recipient of a cardiac graft was used as an organ donor. Death of the recipient occurred 9 days after transplantation and was attributed to presumed cerebral hemorrhage, which post mortem was diagnosed as invasive aspergillosis of the brain. One recipient of a kidney transplant lost the graft due to infection with Aspergillus fumigatus, whereas prompt initiation of therapy successfully prevented disseminated aspergillosis in the other recipients. Despite the pressure to extend the use of organs by lowering the acceptance criteria, organs should only be accepted if the cause of death of the donors is unequivocally explained.

Citations

11 citations in Web of Science®
11 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:20 Jan 2010 08:26
Last Modified:05 Apr 2016 13:45
Publisher:Wiley-Blackwell
ISSN:1398-2273
Publisher DOI:10.1111/j.1399-3062.2009.00463.x
PubMed ID:19804583

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