Greber, U F; Fassati, A (2003). Nuclear import of viral DNA genomes. Traffic, 4(3):136-143.
Full text not available from this repository.
View at publisher
The genomes of many viruses traffic into the nucleus, where they are either integrated into host chromosomes or maintained as episomal DNA and then transcriptionally activated or silenced. Here, we discuss the existing evidence on how the lentiviruses, adenoviruses, herpesviruses, hepadnaviruses and autonomous parvoviruses enter the nucleus. Depending on the size of the capsid enclosing the genome, three principles of viral nucleic acids import are discussed. The first principle is that the capsid disassembles in the cytosol or in a docked state at the nuclear pore complex and a subviral genomic complex is trafficked through the pore. Second, the genome is injected from a capsid that is docked to the pore complex, and third, import factors are recruited to cytosolic capsids to increase capsid affinity to the pore complex, mediate translocation and allow disassembly in the nucleoplasm.
0 downloads since deposited on 11 Feb 2008
0 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||1 March 2003|
|Deposited On:||11 Feb 2008 12:14|
|Last Modified:||27 Nov 2013 19:04|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page