Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-27976

Brentano, F; Kyburz, D; Gay, S (2009). Toll-like receptors and rheumatoid arthritis. In: O'Neill, L A J; McCoy, C E. Toll-Like Receptors. Heidelberg / New York, 329-343. ISBN 978-1-934115-72-5.

[img]
Preview
Accepted Version
PDF
1MB

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that ultimately leads to the progressive destruction of cartilage and bone in numerous joints. There is mounting evidence for an important function of innate immunity in the pathogenesis of RA. Activation of cells by microbial components and also by endogenous molecules via Toll-like receptor (TLR) results in the production of a variety of proinflammatory cytokines, chemokines, and destructive enzymes, some of which can characteristically be found in RA.By immunohistochemistry we found elevated TLR2, 3, and 4 expressions in the rheumatoid synovium. In the synovial lining layer and at sites of invasion into cartilage, RA synovial fibroblasts (RASF) are the major cells expressing TLR2, 3, and 4. Stimulation of cultured RASF in vitro with the TLR2 ligand bacterial lipoprotein (bLP), the TLR3 ligand poly(I-C), and the TLR4 ligand LPS was shown to upregulate IL-6 as well as matrix metalloproteinases (MMPs) 1 and 3. These results suggest an important role for TLR2, 3, and 4 in the activation of synovial fibroblasts in RA leading to chronic inflammation and joint destruction.

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:02 Feb 2010 09:40
Last Modified:23 Nov 2012 13:53
Publisher:Humana Press
Series Name:Methods in Molecular Biology
Number:Volume
ISSN:1064-3745
ISBN:978-1-934115-72-5
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/978-1-59745-541-1_20
PubMed ID:19378024
Citations:Google Scholar™
Scopus®. Citation Count: 21

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page