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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28178

Ergina, P L; Cook, J A; Blazeby, J M; Boutron, I; Clavien, P A; Reeves, B C; Seiler, C M; Altman, D G; Aronson, J K; Barkun, J S; Campbell, W B; Cook, J A; Feldman, L S; Flum, D R; Glasziou, P; Maddern, G J; Marshall, J C; McCulloch, P; Nicholl, J; Strasberg, S M; Meakins, J L; Ashby, D; Black, N; Bunker, J; Burton, M; Campbell, M; Chalkidou, K; Chalmers, I; de Leval, M; Deeks, J; Grant, A; Gray, M; Greenhalgh, R; Jenicek, M; Kehoe, S; Lilford, R; Littlejohns, P; Loke, Y; Madhock, R; McPherson, K; Rothwell, P; Summerskill, B; Taggart, D; Tekkis, P; Thompson, M; Treasure, T; Trohler, U; Vandenbroucke, J (2009). Challenges in evaluating surgical innovation. Lancet, 374(9695):1097-1104.

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Abstract

Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide. In this report, the second of three on surgical innovation and evaluation, we discuss obstacles related to the study design of randomised controlled trials and non-randomised studies assessing surgical interventions. We also describe the issues related to the nature of surgical procedures-for example, their complexity, surgeon-related factors, and the range of outcomes. Although difficult, surgical evaluation is achievable and necessary. Solutions tailored to surgical research and a framework for generating evidence on which to base surgical practice are essential.

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99 citations in Web of Science®
149 citations in Scopus®
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Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:25 Jan 2010 14:47
Last Modified:23 Nov 2012 14:04
Publisher:Elsevier
ISSN:0140-6736
Publisher DOI:10.1016/S0140-6736(09)61086-2
PubMed ID:19782875

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