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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28250

Misselwitz, B; Goede, J S; Pestalozzi, B C; Schanz, U; Seebach, J D (2010). Hyperlipidemic myeloma: review of 53 cases. Annals of Hematology, 89(6):569-577.

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Abstract

Hyperlipidemic myeloma is a rare and poorly understood variant of multiple myeloma. We report the case of a 53-year-old woman with hyperlipidemic myeloma, skin xanthomas and hyperviscosity syndrome who underwent allogeneic bone marrow transplantation. A comprehensive literature search identified 52 additional cases with plasma cell disease and hyperlipidemia. A detailed analysis revealed several characteristics of these patients as compared to multiple myeloma with normal lipid status: (1) IgA paraprotein was present in the majority (53% vs. 21% in classical multiple myeloma). (2) Skin xanthomas, especially in the palmar creases, elbows, and knees were common (70%). (3) Hyperviscosity syndrome occurred more often (26% vs. 2-6%). While conventional lipid-lowering therapy had only marginal effects, successful anti-myeloma therapy also reduced hyperlipidemia. Analyses of the mechanisms leading to hyperlipidemia documented complexes of paraprotein and lipoprotein in 75% of the 32 cases tested, suggesting an inhibitory role of the paraprotein on lipid degradation. In conclusion, the clinical characteristics, the therapeutic options, and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all 53 published cases in the literature.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
DDC:610 Medicine & health
Language:English
Date:17 June 2010
Deposited On:27 Jan 2010 14:44
Last Modified:26 Apr 2014 11:14
Publisher:Springer
ISSN:0939-5555
Publisher DOI:10.1007/s00277-009-0849-9
PubMed ID:19921193
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 6

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