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Meyer, M R; Haas, E; Prossnitz, E R; Barton, M (2009). Non-genomic regulation of vascular cell function and growth by estrogen. Molecular and Cellular Endocrinology, 308(1-2):9-16.

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Abstract

Estrogens exert rapid, non-genomic effects, which are mediated by plasma membrane-associated estrogen receptors (mER) mERalpha and mERbeta, and the intracellular transmembrane G protein-coupled estrogen receptor (GPER). Membrane-initiated responses contribute to transcriptional activation, resulting in a complex interplay of nuclear and extra-nuclear mechanisms that mediate the acute physiological responses to estrogens. Non-genomic estrogen signaling also activates a variety of intracellular estrogen signaling pathways that regulate vascular function and cell growth involving rapid but also long-term effects. This review discusses recent advances in understanding of the mechanisms of non-genomic estrogen receptor signaling in the vascular wall.

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40 citations in Web of Science®
51 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
DDC:610 Medicine & health
Language:English
Date:24 September 2009
Deposited On:27 Jan 2010 14:40
Last Modified:27 Nov 2013 22:11
Publisher:Elsevier
ISSN:0303-7207
Publisher DOI:10.1016/j.mce.2009.03.009
PubMed ID:19549587

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