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Genomic Analysis in Nephrology – towards Systems Biology and Systematic Medicine?


Neusser, M A; Lindenmeyer, M T; Kretzler, M; Cohen, C D (2008). Genomic Analysis in Nephrology – towards Systems Biology and Systematic Medicine? Néphrologie et Thérapeutique, 4(5):306-311.

Abstract

With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.

With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.

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11 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Other titles:Analyse génomique en néphrologie – vers une évaluation systématique?
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:October 2008
Deposited On:25 Aug 2008 09:13
Last Modified:05 Apr 2016 12:24
Publisher:Elsevier
ISSN:1769-7255
Publisher DOI:10.1016/j.nephro.2008.04.003
PubMed ID:18586598
Permanent URL: http://doi.org/10.5167/uzh-2827

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