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Schicker, B; Kuhn, M; Fehr, R; Asmis, L M; Karagiannidis, C; Reinhart, W H (2009). Particulate matter inhalation during hay storing activity induces systemic inflammation and platelet aggregation. European Journal of Applied Physiology, 105(5):771-778.

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The aim of this study was to investigate possible pathomechanisms behind the cardiovascular morbidity caused by inhalation of particulate matter (PM(10)). For that purpose, healthy volunteers were exposed to high PM(10) concentrations during a 2 h hay storing activity. Blood was drawn in the evening before and after PM(10) exposure and in the morning and evening of the day after exposure. The leukocyte count increased after PM(10) exposure with an initial increase of segmented neutrophils followed by banded forms. C-reactive protein increased over time. Fibrinogen and plasma viscosity became increased in the evening of the day after PM(10) exposure. Platelet aggregation was increased in the evening after PM(10) exposure. At the same time von Willebrand factor and factor VIII were increased, reflecting endothelial activation. These results confirm that acute inhalative exposure to high PM(10) concentrations during hay storage activity leads to a systemic inflammatory reaction, endothelial activation, and platelet aggregation.


14 citations in Web of Science®
15 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
Dewey Decimal Classification:610 Medicine & health
Date:6 January 2009
Deposited On:27 Jan 2010 10:39
Last Modified:05 Apr 2016 13:48
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00421-008-0962-9
PubMed ID:19125285

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