Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2829

Maillard, O; Camenisch, U; Blagoev, K; Naegeli, H (2008). Versatile protection from mutagenic DNA lesions conferred by bipartite recognition in nucleotide excision repair. Mutation Research, 658(3):271-286.

[img] PDF - Registered users only
View at publisher


Nucleotide excision repair is a cut-and-patch pathway that eliminates potentially mutagenic DNA lesions caused by ultraviolet light, electrophilic chemicals, oxygen radicals and many other genetic insults. Unlike antigen recognition by the immune system, which employs billions of immunoglobulins and T-cell receptors, the nucleotide excision repair complex relies on just a few generic factors to detect an extremely wide range of DNA adducts. This molecular versatility is achieved by a bipartite strategy initiated by the detection of abnormal strand fluctuations, followed by the localization of injured residues through an enzymatic scanning process coupled to DNA unwinding. The early recognition subunits are able to probe the thermodynamic properties of nucleic acid substrates but avoid direct contacts with chemically altered bases. Only downstream subunits of the bipartite recognition process interact more closely with damaged bases to delineate the sites of DNA incision. Thus, consecutive factors expand the spectrum of deleterious genetic lesions conveyed to DNA repair by detecting distinct molecular features of target substrates.


22 citations in Web of Science®
24 citations in Scopus®
Google Scholar™



2 downloads since deposited on 29 Jul 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:29 Jul 2008 15:32
Last Modified:05 Apr 2016 12:24
Funders:Swiss National Science Foundation, Oncosuisse
Publisher DOI:10.1016/j.mrrev.2008.01.007
PubMed ID:18321768

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page