Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28638
Song, H; Spichiger-Haeusermann, C; Basler, K (2009). The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway. EMBO Reports, 10(10):1140-1146.
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Wingless (Wg) signalling regulates the expression of its target genes through Pangolin, Armadillo and their interacting co-factors. In a genetic screen for Wg signalling components, we found that imitation switch (ISWI), a chromatin-remodelling ATPase, had a positive role in transducing the canonical Wg signal, promoting the expression of the Wg target senseless. ISWI is found in several chromatin-remodelling complexes, including nucleosome remodelling factor (NURF). The effect of interfering with the function of other components of the NURF complex in vivo mimics that of ISWI. The NURF complex is also required for the efficient expression of other Wg target genes. Armadillo interacts directly with the NURF complex in vitro and recruits it to Wg targets in cultured cells. Together, our results suggest that the ISWI-containing NURF complex functions as a co-activator of Armadillo to promote Wg-mediated transcription.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||10 October 2009|
|Deposited On:||02 Feb 2010 16:37|
|Last Modified:||27 Nov 2013 20:20|
|Publisher:||Nature Publishing Group|
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