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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28648

Mosimann, C; Hausmann, G; Basler, K (2009). Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nature Reviews. Molecular Cell Biology, 10(4):276-286.

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Abstract

The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear beta-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that beta-catenin-mediated transcription affects chromatin. How does beta-catenin cope with chromatin regulation to turn on Wnt target genes?

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:10 April 2009
Deposited On:05 Feb 2010 08:49
Last Modified:27 Nov 2013 20:09
Publisher:Nature Publishing Group
ISSN:1471-0072
Publisher DOI:10.1038/nrm2654
PubMed ID:19305417
Citations:Web of Science®. Times Cited: 175
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Scopus®. Citation Count: 185

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