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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28687

Kuhn, M; Szklarczyk, D; Franceschini, A; Campillos, M; von Mering, C; Jensen, L J; Beyer, A; Bork, P (2010). STITCH 2: an interaction network database for small molecules and proteins. Nucleic Acids Research, 38 (Da:D552-D556.

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Abstract

Over the last years, the publicly available knowledge on interactions between small molecules and proteins has been steadily increasing. To create a network of interactions, STITCH aims to integrate the data dispersed over the literature and various databases of biological pathways, drug-target relationships and binding affinities. In STITCH 2, the number of relevant interactions is increased by incorporation of BindingDB, PharmGKB and the Comparative Toxicogenomics Database. The resulting network can be explored interactively or used as the basis for large-scale analyses. To facilitate links to other chemical databases, we adopt InChIKeys that allow identification of chemicals with a short, checksum-like string. STITCH 2.0 connects proteins from 630 organisms to over 74,000 different chemicals, including 2200 drugs. STITCH can be accessed at http://stitch.embl.de/.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
08 University Research Priority Programs > Systems Biology / Functional Genomics
DDC:570 Life sciences; biology
Language:English
Date:2010
Deposited On:21 Mar 2010 10:12
Last Modified:27 Nov 2013 23:24
Publisher:Oxford University Press
ISSN:0305-1048
Publisher DOI:10.1093/nar/gkp937
PubMed ID:19897548
Citations:Web of Science®. Times Cited: 78
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