Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-2881

Aicher, W K; Pap, T; Gay, S (2008). Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten. Zeitschrift für Rheumatologie, 67(1):59-61.

[img] PDF - Registered users only
1MB

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.

Other titles:Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
DDC:570 Life sciences; biology
610 Medicine & health
Language:German
Date:2008
Deposited On:05 Aug 2008 09:10
Last Modified:28 Nov 2013 01:20
Publisher:Springer
ISSN:0340-1855
Publisher DOI:10.1007/s00393-008-0261-1
PubMed ID:18214499
Citations:Web of Science®. Times Cited: 1
Google Scholar™
Scopus®. Citation Count: 1

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page