Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-28845

Sostak, C; Padovan, C S; Eigenbrod, S; Roeber, S; Segerer, S; Schankin, C; Siegert, S; Saam, T; Theil, D; Kolb, H J; Kretzschmar, H; Straube, A (2010). Cerebral angiitis in four patients with chronic GVHD. Bone Marrow Transplantation, 45(7):1181-1188.

[img] PDF - Registered users only
View at publisher


There is growing evidence that GVHD affects the central nervous system (CNS). In this study, we describe the long-term follow-up of four allogeneic BM recipients who developed cerebral angiitis-like disease probably due to GVHD. The patients developed focal neurological signs, cognitive deficits and/or coma in association with GVHD, 2–18 years after transplantation, following reduction of immunosuppressive therapy. Magnetic resonance imaging was variable, showing generalized brain atrophy, ischemic lesions or leukoencephalopathy. Diagnosis of cerebral angiitis was confirmed by histopathological analysis of bioptic brain tissue and response to immunosuppressive therapy. By means of immunohistochemistry and immunofluorescence, perivascular lymphomononuclear cerebral infiltrates were shown to express the adhesion receptor, CD11a, and the chemokine receptor, CCR5. Our findings imply that GVHD should be considered in the differential diagnosis of noninfectious angiitis-like disease of the CNS in long-term survivors after allogeneic BMT. Infiltrating cells, in analogy to typical target organs of GVHD such as skin or liver, expressed CD11a and CCR5. These findings could be of etiopathological, diagnostic and therapeutic relevance.


9 citations in Web of Science®
14 citations in Scopus®
Google Scholar™



3 downloads since deposited on 05 Feb 2010
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:15 July 2010
Deposited On:05 Feb 2010 07:20
Last Modified:05 Apr 2016 13:50
Publisher:Nature Publishing Group
Publisher DOI:10.1038/bmt.2009.323
PubMed ID:19915632

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page