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Onai, N; Manz, M G; Schmid, M A (2010). Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. In: Naik, S H. Dendritic Cell Protocols. United States: Springer / Humana Press, 195-203.

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In the steady-state lymphoid organ, dendritic cells (DCs) are classified into two major subsets, plasmacytoid DC (pDC) and conventional DC (cDC). A standing question was whether a common progenitor for plasmacytoid and conventional dendritic cells exists during the sequential differentiation from hematopoietic stem cells to dendritic cells. We have recently identified such a common clonogenic plasmacytoid and dendritic cell progenitor (CDP) from mouse bone marrow using antibodies for c-kit, Flt3, and M-CSFR. CDPs generated almost exclusively pDC and cDC in vitro and upon transfer in irradiated and steady-state mice in vivo. Single-cell analysis revealed the existence of clonal progenitors giving rise to both pDC and cDC within the CDP population. Thus, these results prove the existence of a common developmental pathway for at least some pDCs and cDCs in lymphoid organs in vivo.


8 citations in Web of Science®
9 citations in Scopus®
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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
Dewey Decimal Classification:610 Medicine & health
Deposited On:02 Mar 2010 14:15
Last Modified:05 Apr 2016 13:51
Publisher:Springer / Humana Press
Series Name:Methods in Molecular Biology
Number:Volume 595 / Part 3
ISSN:1064-3745 (P) 1940-6029 (E)
ISBN:978-1-60761-420-3 (P) 978-1-60761-421-0 (E)
Publisher DOI:10.1007/978-1-60761-421-0_13
PubMed ID:19941114

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