Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Onai, N; Manz, M G; Schmid , M A (2010). Isolation of common dendritic cell progenitors (CDP) from mouse bone marrow. In: Naik, S H. Dendritic Cell Protocols. United States, 195-203. ISBN 978-1-60761-420-3 (P) 978-1-60761-421-0 (E).

Full text not available from this repository.

View at publisher

Abstract

In the steady-state lymphoid organ, dendritic cells (DCs) are classified into two major subsets, plasmacytoid DC (pDC) and conventional DC (cDC). A standing question was whether a common progenitor for plasmacytoid and conventional dendritic cells exists during the sequential differentiation from hematopoietic stem cells to dendritic cells. We have recently identified such a common clonogenic plasmacytoid and dendritic cell progenitor (CDP) from mouse bone marrow using antibodies for c-kit, Flt3, and M-CSFR. CDPs generated almost exclusively pDC and cDC in vitro and upon transfer in irradiated and steady-state mice in vivo. Single-cell analysis revealed the existence of clonal progenitors giving rise to both pDC and cDC within the CDP population. Thus, these results prove the existence of a common developmental pathway for at least some pDCs and cDCs in lymphoid organs in vivo.

Citations

5 citations in Web of Science®
7 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:02 Mar 2010 14:15
Last Modified:27 Nov 2013 17:26
Publisher:Springer / Humana Press
Series Name:Methods in Molecular Biology
Number:Volume 595 / Part 3
ISSN:1064-3745 (P) 1940-6029 (E)
ISBN:978-1-60761-420-3 (P) 978-1-60761-421-0 (E)
Publisher DOI:10.1007/978-1-60761-421-0_13
PubMed ID:19941114

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page