Legrand, N; Ploss, A; Balling, R; Becker, P D; Borsotti, C; Brezillon, N; Debarry, J; De Jong, Y; Deng, H; Di Santo, J P; Eisenbarth, S; Eynon, E; Flavell, R A; Guzman, C A; Huntington, N D; Kremsdorf, D; Manns, M P; Manz, M G; Mention, J J; Ott, M; Rathinam, C; Rice , C M; Rongvaux, A; Stevens, S; Spits, H; Strick-Marchand, H; Takizawa, H; van Lent, A U; Wang, C; Weijer, K; Willinger, T; Ziegler, P (2009). Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host & Microbe, 6(1):5-9.
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Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology|
|DDC:||610 Medicine & health|
|Date:||23 July 2009|
|Deposited On:||02 Mar 2010 15:35|
|Last Modified:||28 Nov 2013 00:26|
|Citations:||Web of Science®. Times cited: 86|
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