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Legrand, N; Ploss, A; Balling, R; Becker, P D; Borsotti, C; Brezillon, N; Debarry, J; De Jong, Y; Deng, H; Di Santo, J P; Eisenbarth, S; Eynon, E; Flavell, R A; Guzman, C A; Huntington, N D; Kremsdorf, D; Manns, M P; Manz, M G; Mention, J J; Ott, M; Rathinam, C; Rice , C M; Rongvaux, A; Stevens, S; Spits, H; Strick-Marchand, H; Takizawa, H; van Lent, A U; Wang, C; Weijer, K; Willinger, T; Ziegler, P (2009). Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host & Microbe, 6(1):5-9.

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Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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93 citations in Web of Science®
92 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
DDC:610 Medicine & health
Language:English
Date:23 July 2009
Deposited On:02 Mar 2010 14:35
Last Modified:27 Nov 2013 23:26
Publisher:Elsevier
ISSN:1931-3128
Publisher DOI:10.1016/j.chom.2009.06.006
PubMed ID:19616761

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