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Humanized mice for modeling human infectious disease: challenges, progress, and outlook


Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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128 citations in Web of Science®
124 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Hematology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:23 July 2009
Deposited On:02 Mar 2010 14:35
Last Modified:05 Apr 2016 13:51
Publisher:Elsevier
ISSN:1931-3128
Publisher DOI:10.1016/j.chom.2009.06.006
PubMed ID:19616761

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