Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-293
Greber, U F; Gastaldelli, M (2007). Junctional gating: the achilles' heel of epithelial cells in pathogen infection. Cell Host & Microbe, 2(3):143-146.
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| Accepted Version 175Kb |
Abstract
Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Institute of Molecular Life Sciences |
| DDC: | 570 Life sciences; biology |
| Language: | English |
| Date: | 13 September 2007 |
| Deposited On: | 11 Feb 2008 13:14 |
| Last Modified: | 23 Nov 2012 15:33 |
| Publisher: | Elsevier |
| ISSN: | 1931-3128 |
| Publisher DOI: | 10.1016/j.chom.2007.08.004 |
| PubMed ID: | 18005729 |
| WoS Citation Count: | 13 |
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