Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-293
Greber, U F; Gastaldelli, M (2007). Junctional gating: the achilles' heel of epithelial cells in pathogen infection. Cell Host & Microbe, 2(3):143-146.
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Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Date:||13 September 2007|
|Deposited On:||11 Feb 2008 12:14|
|Last Modified:||28 Nov 2013 01:04|
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