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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-293

Greber, U F; Gastaldelli, M (2007). Junctional gating: the achilles' heel of epithelial cells in pathogen infection. Cell Host & Microbe, 2(3):143-146.

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Abstract

Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:13 September 2007
Deposited On:11 Feb 2008 12:14
Last Modified:28 Nov 2013 01:04
Publisher:Elsevier
ISSN:1931-3128
Publisher DOI:10.1016/j.chom.2007.08.004
PubMed ID:18005729
Citations:Web of Science®. Times Cited: 14
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Scopus®. Citation Count: 13

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