Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-29607

Kunz, P C; Kassack, M U; Hamacher, A; Spingler, B (2009). Imidazole-based phosphane gold(I) complexes as potential agents for cancer treatment: Synthesis, structural studies and antitumour activity. Dalton Transactions, 2009(37):7741-7747.

[img]
Preview
Accepted Version
PDF
1MB

View at publisher
[img] PDF - Registered users only
1MB

Abstract

The reaction of the imidazolyl-4(5)-phosphane ligands 2-isopropylimidazol-4(5)yl-diphenylphosphane (4-MIP(iPr)) and tris(2-isopropylimidazol-4(5)yl)phosphane (4-TIP(iPr)) towards gold(I) has been explored and compared to those of analogous 1-methylimidazol-2-ylphosphane ligands. The structure of [(4-MIP(iPr))AuCl] () shows a linear P-Au-Cl coordination, whereas the 4-TIP(iPr) ligand forms a dinuclear complex [{(4-TIP(iPr))Au}(2)]Cl(2) (). Here, 4-TIP(iPr) bridges two gold(I) atoms in a head-to-tail P,N fashion. Complex forms in the presence of the hard Lewis acid ZnCl(2) the bimetallic complex [AuCl(4-TIP(iPr))ZnCl]Cl (), in which 4-TIP(iPr) bridges the two metal centers. In accordance with the HSAB concept the Au(I) atom is coordinated by the P atom and the zinc(II) by three N atoms in a N,N,N fashion. The solid-state structures of the complexes have been elucidated by single-crystal X-ray analysis. The Au(I)-Au(I) contact in is 2.8821(15) A. The biological activities of all imidazol-2-yl- and imidazol-4(5)-ylphosphane gold(I) complexes towards nine human cancer cell lines including seven ovarian cancer cell lines of different sensitivity towards cisplatin and two leukemia cell lines have been explored.

Citations

15 citations in Web of Science®
16 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

33 downloads since deposited on 05 Feb 2010
23 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
DDC:540 Chemistry
Language:English
Date:2009
Deposited On:05 Feb 2010 14:54
Last Modified:27 Nov 2013 18:34
Publisher:Royal Society of Chemistry
ISSN:1477-9226
Additional Information:Persons who receive the PDF must not make it further available or distribute it.
Publisher DOI:10.1039/b902748c
PubMed ID:19759948

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page