Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-29655

Stober, G; Ben-Shachar, D; Cardon, M; Falkai, P; Fonteh, A N; Gawlik, M; Glenthoj, B Y; Grünblatt, E; Jablensky, A; Kim, Y K; Kornhuber, J; McNeil, T F; Muller, N; Oranje, B; Saito, T; Saoud, M; Schmitt, A; Schwartz, M; Thome, J; Uzbekov, M; Durany, N; Riederer, P (2009). Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. World Journal of Biological Psychiatry, 10(2):127-155.

[img] PDF - Registered users only
View at publisher


Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.


34 citations in Web of Science®
47 citations in Scopus®
Google Scholar™



0 downloads since deposited on 08 Feb 2010
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
Dewey Decimal Classification:610 Medicine & health
Deposited On:08 Feb 2010 11:18
Last Modified:05 Apr 2016 13:52
Publisher:Informa Healthcare
Publisher DOI:10.1080/15622970902898980
PubMed ID:19396704

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page