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Pitfall: Pemphigus herpeticatus should not be confounded with resistant pemphigus vulgaris


Feldmeyer, L; Trüeb, R M; French, L E; Hafner, J (2010). Pitfall: Pemphigus herpeticatus should not be confounded with resistant pemphigus vulgaris. Journal of Dermatological Treatment, 21(5):311-313.

Abstract

Human herpes simplex virus (HSV) infections are well-recognized complications of various dermatoses and have also been reported in both hereditary and acquired acantholytic diseases such as dyskeratosis follicularis (Darier's disease), familial benign chronic pemphigus (Hailey-Hailey disease) and pemphigus vulgaris, respectively. The possibility of HSV infection should be considered in pemphigus patients with lack of improvement under adequate immunosuppressive therapy. This has therapeutic implications, since antiviral treatment instantly clears the HSV-induced chronic erosions. Instead, augmentation or change of immune suppression for assumed refractory pemphigus will obviously not improve the condition. We suggest using the diagnostic term pemphigus herpeticatus to describe HSV-superinfected pemphigus, alluding to the pathophysiologic analogies with eczema herpeticatum.

Human herpes simplex virus (HSV) infections are well-recognized complications of various dermatoses and have also been reported in both hereditary and acquired acantholytic diseases such as dyskeratosis follicularis (Darier's disease), familial benign chronic pemphigus (Hailey-Hailey disease) and pemphigus vulgaris, respectively. The possibility of HSV infection should be considered in pemphigus patients with lack of improvement under adequate immunosuppressive therapy. This has therapeutic implications, since antiviral treatment instantly clears the HSV-induced chronic erosions. Instead, augmentation or change of immune suppression for assumed refractory pemphigus will obviously not improve the condition. We suggest using the diagnostic term pemphigus herpeticatus to describe HSV-superinfected pemphigus, alluding to the pathophysiologic analogies with eczema herpeticatum.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:08 Mar 2010 09:09
Last Modified:05 Apr 2016 13:52
Publisher:Informa Healthcare
ISSN:0954-6634
Publisher DOI:https://doi.org/10.3109/09546630903287452
PubMed ID:19895326
Permanent URL: https://doi.org/10.5167/uzh-29764

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