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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-29767

Georgi, A; Schneemann, M; Tintelnot, K; Calligaris-Maibach, R C; Meyer, S; Weber, R; Bosshard, P P (2009). Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure. Infection, 37(4):370-373.

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A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
DDC:610 Medicine & health
Deposited On:15 Feb 2010 16:31
Last Modified:02 Dec 2013 18:24
Publisher DOI:10.1007/s15010-008-8211-z
PubMed ID:19390780
Citations:Web of Science®. Times Cited: 23
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Scopus®. Citation Count: 27

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