Cattori, V; Hagenbuch, B; Hagenbuch, N; Stieger, B; Ha, R; Winterhalter, K E; Meier, P J (2000). Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver. FEBS Letters, 474(2-3):242-245.
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Abstract
A novel organic anion transporting polypeptide (Oatp)4(1) was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)-1 and exhibits a 64% amino acid sequence identity with the human OATP-C (LST-1/OATP2; gene symbol SLC21A6). When expressed in Xenopus laevis oocytes, Oatp4 (Slc21a10) mediated polyspecific uptake of a variety of organic anions including taurocholate (K(m) approximately 27 microM), bromosulfophthalein (K(m) approximately 1.1 microM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst-1 plays a minor role in overall hepatic organic anion uptake.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology |
| DDC: | 610 Medicine & health |
| Language: | English |
| Date: | 02 June 2000 |
| Deposited On: | 08 Apr 2009 11:53 |
| Last Modified: | 04 Apr 2012 14:16 |
| Publisher: | Elsevier |
| ISSN: | 0014-5793 |
| Additional Information: | Elsevier - Full-text article at http://linkinghub.elsevier.com/retrieve/pii/S0014579300015969 |
| Publisher DOI: | 10.1016/S0014-5793(00)01596-9 |
| PubMed ID: | 10838093 |
| WoS Citation Count: | 101 |
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