Cattori, V; Eckhardt, U; Hagenbuch, B (1999). Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1. Biochimica et Biophysica Acta, 1445(1):154-159.
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Abstract
To isolate the murine Na+/taurocholate cotransporting polypeptide (Ntcp), we screened a mouse liver cDNA library and identified Ntcp1, encoding a 362 amino acid protein and Ntcp2, encoding a 317 amino acid protein which had a shorter C-terminal end. Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology |
| DDC: | 610 Medicine & health |
| Language: | English |
| Date: | 14 April 1999 |
| Deposited On: | 08 Apr 2009 11:32 |
| Last Modified: | 23 Nov 2012 16:39 |
| Publisher: | Elsevier |
| ISSN: | 0006-3002 |
| PubMed ID: | 10209268 |
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