Cattori, V; Eckhardt, U; Hagenbuch, B (1999). Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1. Biochimica et Biophysica Acta, 1445(1):154-159.
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To isolate the murine Na+/taurocholate cotransporting polypeptide (Ntcp), we screened a mouse liver cDNA library and identified Ntcp1, encoding a 362 amino acid protein and Ntcp2, encoding a 317 amino acid protein which had a shorter C-terminal end. Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology|
|DDC:||610 Medicine & health|
|Date:||14 April 1999|
|Deposited On:||08 Apr 2009 11:32|
|Last Modified:||28 Nov 2013 00:18|
|Citations:||Web of Science®. Times cited: 35|
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