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Cattori, V; Eckhardt, U; Hagenbuch, B (1999). Molecular cloning and functional characterization of two alternatively spliced Ntcp isoforms from mouse liver1. Biochimica et Biophysica Acta, 1445(1):154-159.

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Abstract

To isolate the murine Na+/taurocholate cotransporting polypeptide (Ntcp), we screened a mouse liver cDNA library and identified Ntcp1, encoding a 362 amino acid protein and Ntcp2, encoding a 317 amino acid protein which had a shorter C-terminal end. Both isoforms mediated saturable Na+-dependent transport of taurocholate when expressed in Xenopus laevis oocytes. Analysis of the gene revealed that Ntcp2 is produced by alternative splicing where the last intron is retained.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
DDC:610 Medicine & health
Language:English
Date:14 April 1999
Deposited On:08 Apr 2009 09:32
Last Modified:27 Nov 2013 23:18
Publisher:Elsevier
ISSN:0006-3002
Publisher DOI:10.1016/S0167-4781(99)00029-9
PubMed ID:10209268

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