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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3007

Tandon, R; Cattori, V; Pepin, A C; Riond, B; Meli, M L; McDonald, M; Doherr, M G; Lutz, H; Hofmann-Lehmann, R (2008). Association between endogenous feline leukemia virus loads and exogenous feline leukemia virus infection in domestic cats. Virus Research, 135(1):136-143.

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Abstract

Recently, we demonstrated that endogenous feline leukemia virus (enFeLV) loads may vary among cats of different populations and that FeLV-infected cats have higher enFeLV loads than uninfected cats. Thus, we hypothesized that enFeLV might influence the pathogenesis and outcome of FeLV infection. No significant difference in the infection outcome (regressive versus progressive infection) was observed between groups of cats with high or low enFeLV loads following FeLV-A challenge. However, cats with high enFeLV loads showed higher viral replication (plasma viral RNA and p27 antigen levels) than cats with low enFeLV loads in the early phase of the infection. The enFeLV transcription level varied at different time points, but no clear-cut pattern was observed. In conclusion, our results demonstrated an association between enFeLV loads and FeLV replication but not outcome of infection. enFeLV should be considered as an important confounder in experimental FeLV infection or vaccination studies.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinical Laboratory
DDC:570 Life sciences; biology
630 Agriculture
Language:English
Date:2008
Deposited On:12 Aug 2008 06:41
Last Modified:27 Nov 2013 20:41
Publisher:Elsevier
ISSN:0168-1702
Publisher DOI:10.1016/j.virusres.2008.02.016
PubMed ID:18407367
Citations:Web of Science®. Times Cited: 6
Google Scholar™
Scopus®. Citation Count: 6

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