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Tissue-engineered trachea: History, problems and the future


Tan, Q; Steiner, R; Hoerstrup, S P; Weder, W (2006). Tissue-engineered trachea: History, problems and the future. European Journal of Cardio-Thoracic Surgery, 30(5):782-786.

Abstract

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.

This review tries to summarize the efforts over the past 20 years to construct a tissue-engineered trachea. After illustrating the main technical bottlenecks faced nowadays, we discuss what might be the solutions to these bottlenecks. You may find out why the focus in this research field shifts dramatically from the construction of a tubular cartilage tissue to reepithelialization and revascularization of the prosthesis. In the end we propose a novel concept of 'in vivo bioreactor', defined as the design of a perfusion system inside the scaffold, and explain its potential application in the construction of a tissue-engineered trachea.

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28 citations in Web of Science®
29 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Date:2006
Deposited On:24 Mar 2010 07:14
Last Modified:05 Apr 2016 13:53
Publisher:Elsevier
ISSN:1010-7940
Publisher DOI:https://doi.org/10.1016/j.ejcts.2006.08.023
PubMed ID:17011786
Permanent URL: https://doi.org/10.5167/uzh-30084

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