Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Han, J H; Kushner, S A; Yiu, A P; Hsiang, H L; Buchanan, T; Waisman, A; Bontempi, B; Neve, R L; Frankland, P W; Josselyn, S A (2009). Selective erasure of a fear memory. Science, 323(5920):1492-1496.

Full text not available from this repository.

View at publisher

Abstract

Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased cyclic adenosine monophosphate response element-binding protein (CREB) are preferentially activated by fear memory expression, which suggests that they are selectively recruited into the memory trace. We used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, which suggests that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace.

Citations

144 citations in Web of Science®
146 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 12 Feb 2010
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:12 Feb 2010 08:01
Last Modified:27 Nov 2013 22:33
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Publisher DOI:10.1126/science.1164139
PubMed ID:19286560

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page