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Durieux, P F; Bearzatto, B; Guiducci, S; Buch, T; Waisman, A; Zoli, M; Schiffmann, S N; de Kerchove d'Exaerde, A (2009). D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nature Neuroscience, 12(4):393-395.

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Abstract

The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.

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76 citations in Web of Science®
79 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:11 Feb 2010 19:25
Last Modified:28 Nov 2013 00:49
Publisher:Nature Publishing Group
ISSN:1097-6256
Publisher DOI:10.1038/nn.2286
PubMed ID:19270687

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