Quick Search:

is currently disabled due to reindexing of the ZORA database. Please use Advanced Search.
uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Düber, S; Hafner, M; Krey, M; Lienenklaus, S; Roy, B; Hobeika, E; Reth, M; Buch, T; Waisman, A; Kretschmer, K; Weiss, S (2009). Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells. Blood, 114(24):4960-4967.

Full text not available from this repository.

Abstract

To study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)-targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell-specific restoration of a functional Rag1 transcription unit. Follicular and marginal zone B cells populated the spleen when Rag1 expression was permitted. Notably, the peritoneal cavity was dominated by bona fide B-1a cells, as judged by surface markers and functional properties. These BM-derived B-1a cells exhibited a polyclonal VDJ repertoire with substantial N nucleotide insertions. Nevertheless, physiologic frequencies of phosphatidylcholine-specific B cells were detected. Importantly, the BM of young and 5-month-old mice was indistinguishable with regard to the potential to generate B-1a cells.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:11 Feb 2010 19:20
Last Modified:27 Nov 2013 23:31
Publisher:American Society of Hematology
ISSN:0006-4971
Publisher DOI:10.1182/blood-2009-04-218156
PubMed ID:19812384
Citations:Web of Science®. Times Cited: 20
Google Scholar™
Scopus®. Citation Count: 25

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page